Elevate Proliferation, Viability, and Therapy Potential
Reduce variability concerns with TheraPEAK® T-VIVO® Cell Culture Medium and achieve greater cell proliferation and viability, along with increased process efficiencies. Its novel chemically defined formulation is serum-free and non-animal origin (NAO), ensuring consistency and increased process control. Unlike many other serum-free media, this new medium does not need the addition of human serum (HS) to achieve the desired performance.
TheraPEAK® T-VIVO® Medium enhances the culture and expansion of:
αβ and γδ T cells
CAR-T cells
Peripheral blood lymphocytes (PBL)
Tumor infiltrating lymphocytes (TIL)
With traceability documentation available, including Certificates of Analysis and a Drug Master File, TheraPEAK® T-VIVO® Cell Culture Medium simplifies processes, supports regulatory compliance, and scale up from preclinical development through to manufacturing.
TheraPEAK® T-VIVO® Cell Culture Medium is available as 1 L bottle or 1 L bag. Customization of packaging for specific applications is available.
Features and benefits at a glance
NAO formulation; contains only recombinant proteins
Does not require serum or serum component addition
Greater cell proliferation
Easy-to-use formulation only requiring addition of cytokines
High transduction efficiencies and post-transduction viabilities
Optimal performance across different platforms and T cell types
T-cell expansion in TheraPEAK® T-VIVO® Medium compared with other commercial media in a gas-permeable cell expansion device
TheraPEAK® T-VIVO® Cell Culture Medium supports efficient T-cell expansion in a gas-permeable cell expansion device compared with various commercial media. All culture media are supplemented with recombinant human IL-2 (100 IU/mL). Each donor is represented by the ▲■● symbol. Human AB serum (5%) is also added to each medium for comparison purpose (black symbols). Medium G and RPMI-1640 do not support T cell growth without the supplementation of human AB serum.
T-cell expansion in TheraPEAK® T-VIVO® Medium compared with other commercial media in a gas-permeable cell expansion device
TheraPEAK® T-VIVO® Cell Culture Medium supports efficient T-cell expansion in a gas-permeable cell expansion device compared with various commercial media. All culture media are supplemented with recombinant human IL-2 (100 IU/mL). Each donor is represented by the ▲■● symbol. Human AB serum (5%) is also added to each medium for comparison purpose (black symbols). Medium G and RPMI-1640 do not support T cell growth without the supplementation of human AB serum.
Scale-up of T-cell expansion in rocking motion platform and spinner flask using TheraPEAK® T-VIVO® Medium
Full-scale T-cell expansion in spinner flask or rocking motion platform bioreactor. Peripheral blood mononuclear cells are activated via CD3 and CD28 and expanded with TheraPEAK® T-VIVO® Medium for up to 12 days. TheraPEAK® T-VIVO® Medium is supplemented with recombinant human IL-2 (100 IU/mL).
Would you like to see more data? View our scientific posters
A Novel, Chemically Defined Medium Supports Superior Cross-platform T-cell Expansion
Scale-up of T-cell expansion in rocking motion platform and spinner flask using TheraPEAK® T-VIVO® Medium
Full-scale T-cell expansion in spinner flask or rocking motion platform bioreactor. Peripheral blood mononuclear cells are activated via CD3 and CD28 and expanded with TheraPEAK® T-VIVO® Medium for up to 12 days. TheraPEAK® T-VIVO® Medium is supplemented with recombinant human IL-2 (100 IU/mL).
Would you like to see more data? View our scientific poster
A Novel, Chemically Defined Medium Supports Superior Cross-plattform T-cell Expansion
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*Terms and conditions apply. All TheraPEAK® Products are produced according to applicable GMP standards and follow the USP/EP guidance for cell and gene therapy raw materials. It is the end user’s responsibility to ensure full compliance with all regulations based on their use of Lonza’s products in their specific process. TheraPEAK® Media Products are produced at FDA registered manufacturing sites with an ISO 13485 certified quality management system. This product is not for human or animal in vivo use, including use as a diluent or as an excipient, or for diagnostic use. This product is for use in GMP manufacturing processes or research use only. All trademarks belong to Lonza, registered in USA, EU or CH or to third party owners and are used only for informational purposes. The information contained herein is believed to be correct. No warranty is made, either expressed or implied. For more details: lonza.com/legal
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